Indications
Acerux-H cream is used for early treatment of recurrent herpes labialis (cold sores). Starting treatment promptly at the first signs helps prevent the sores from progressing to the ulcer stage and helps the lesion heal faster. It is suitable for adults and children aged 6 years and above.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Acyclovir is a synthetic purine nucleoside analogue that inhibits Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), both in cell culture and in the body. Its inhibitory action is highly selective because it has a strong affinity for thymidine kinase (TK), an enzyme encoded by HSV. This viral enzyme converts Acyclovir into Acyclovir monophosphate, a nucleotide analogue, which is then converted into diphosphate by cellular guanylate kinase and finally into triphosphate by several cellular enzymes. In cell culture, Acyclovir triphosphate halts replication of herpes viral DNA through 3 mechanisms: competitive inhibition of viral DNA polymerase, incorporation into the growing viral DNA chain (causing its termination), and inactivation of the viral DNA polymerase.
Hydrocortisone is the principal glucocorticoid secreted by the adrenal cortex. Applied topically, it produces anti-inflammatory effects that ease the clinical symptoms of a wide range of disorders in which inflammation is a prominent feature.
Pregnancy & Breastfeeding
Pregnancy Category B. There are no adequate and well-controlled studies of systemic Acyclovir in pregnant women, and no studies have been performed in this group. However, systemic exposure to Acyclovir and Hydrocortisone after topical use of this cream is minimal. It is not known whether topically applied Acyclovir or Hydrocortisone passes into breast milk. Since many drugs are excreted in human milk, caution should be exercised when this medicine is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.