Bosentan Monohydrate Ritonavir
ModerateRitonavir is a CYP3A4 inhibitor, and taking it with Bosentan Monohydrate can raise the amount of bosentan in your blood. Other CYP3A4 inhibitors, such as ketoconazole and diltiazem, do the same. So do CYP2C9 inhibitors, such as amiodarone and fluconazole, and tacrolimus.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.