Taking Multivitamin & Multimineral [A-Z junior infusion preparation] together with Methotrexate can weaken how well Methotrexate works. This is because the folic acid in the vitamin preparation can reduce the response to Methotrexate treatment.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.