Studies show that Nevola (desvenlafaxine) at 100 mg daily has no clinically relevant effect on how the body breaks down medicines through the CYP2D6 enzyme. Metoprolol is one of these medicines. The others are desipramine, atomoxetine, dextromethorphan, nebivolol, perphenazine and tolterodine. So at this dose, taking Nevola with metoprolol should not change how much metoprolol your body handles.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.