Ponatinib Hydrochloride Nelfinavir
ModerateNelfinavir is a strong CYP3A inhibitor, meaning it slows down the enzyme that helps the body break down ponatinib. Taking the two together can therefore raise the amount of ponatinib in your body. Your doctor should be careful about this combination and may consider starting ponatinib at a lower dose of 30 mg. Do not change your dose on your own. Let your doctor know if you are taking nelfinavir.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.