Ampicillin Sodium Methotrexate
ModerateAmpicillin reduces renal clearance of methotrexate, raising levels and toxicity (myelosuppression, mucositis).
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.
Clinical management: Monitor methotrexate levels and blood counts; adjust dose.