Tizanidine Hydrochloride Rifampicin
ModerateTaking tizanidine together with rifampicin can cut the level of tizanidine in your blood by half (50%). Because of this, tizanidine may not work as well while you are on rifampicin, and for some people this drop matters in practice.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.