Disopyramide can increase the effects of insulin lispro protamine and insulin lispro. Other medicines in the same list, such as oral antidiabetic agents, ACE inhibitors, MAOIs, and sulfonamide antibiotics, can also make these insulins work more strongly.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.