17 β Estradiol Ketoconazole
ModerateKetoconazole inhibits CYP3A4, an enzyme that helps clear 17 β estradiol from the body. Taking the two together can raise the level of estrogen in the blood, and this may cause adverse reactions.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.