17 β Estradiol Hypericum Perforatum
ModerateHypericum perforatum (St. John's wort) can lower the level of 17 β estradiol in the blood. This may make estradiol work less well, and it may also change the pattern of uterine bleeding.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.