Pioglitazone + Glimepiride Ibuprofen
ModerateGlimepiride is broken down by the cytochrome P450 2C9 enzyme, and so are phenytoin, diclofenac, ibuprofen, naproxen and mefenamic acid. So these medicines may interact with it.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.