Taking relugolix, estradiol and norethindrone together with a medicine that is both a P-gp inducer and a strong CYP3A inducer lowers the AUC and Cmax of the estradiol in this combination. That can make the tablet work less well.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.