Selexipag Rifampicin
ModerateRifampicin, taken with Selexipag, can lower the amount of the active metabolite of Selexipag in your blood, because it speeds up the enzyme CYP2C8 that breaks it down. This means Selexipag may not work as well. The leaflet also says the dose of Selexipag may need to be increased up to twice the usual dose when the two are taken together.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.