Upadacitinib Ketoconazole
ModerateTaking upadacitinib together with ketoconazole raises the amount of upadacitinib in your body. Ketoconazole blocks the CYP3A4 enzyme, which normally breaks upadacitinib down, so the level of the drug goes up.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.