Crizotinib Atazanavir
MajorCrizotinib and atazanavir should not be taken together. Atazanavir is a strong CYP3A inhibitor, which means it interferes with an enzyme (CYP3A) that helps the body process crizotinib. Because of this, the leaflet advises avoiding the combination. If you are on atazanavir, talk to your doctor before starting crizotinib. Do not stop or change either medicine on your own.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.