Ifosfamide Phenobarbital
ModeratePhenobarbital is one of the medicines that can speed up the breakdown of ifosfamide. It does this by boosting CYP3A4, the liver enzyme that processes ifosfamide, so the body clears it faster and the medicine may not work as well as it should.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.