Mefenamic Acid Pioglitazone + Glimepiride
ModerateGlimepiride is broken down by the liver enzyme cytochrome P450 2C9, and mefenamic acid is another medicine that uses the same enzyme. Because the two compete for it, they may interact with each other when taken together.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.