Taking diclofenac sodium with misoprostol together with aspirin is not recommended. Aspirin pushes diclofenac off the blood proteins carrying it, so less diclofenac reaches your body.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
What to do: Do not take these together unless your doctor has told you to. Ask your doctor or pharmacist first.