Palcigen Palbociclib Posaconazole
MajorPosaconazole slows down the liver enzyme (CYP3A) that breaks down Palbociclib. If you take the two together, more Palbociclib stays in your body than intended. Posaconazole is one of the strong medicines of this kind, so the leaflet says to avoid taking them together. If you are on Posaconazole, talk to your doctor before starting Palbociclib.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.