Supraphen plus Chloramphenicol + Lidocaine Hydrochloride Phenytoin
MajorChloramphenicol, which is given in this combination with lidocaine, can be fatal when taken with phenytoin. It can increase the effect of phenytoin, so the two should not be taken together without a doctor's close review.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.