D-Lina M Linagliptin + Metformin Hydrochloride Rifampicin
ModerateRifampicin (rifampin) can lower the amount of linagliptin in the body when it is taken with linagliptin and metformin. Because of this, linagliptin may not work as well, since rifampicin is a strong inducer of P-glycoprotein and CYP3A4 enzymes.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.