Quetinil XR 50 Quetiapine Itraconazole
MajorStrong CYP3A4 inhibition greatly raises quetiapine levels, causing sedation, hypotension and QT prolongation.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Reduce quetiapine dose to about one-sixth, or avoid the combination. Monitor ECG and blood pressure.