Orogurd Miconazole Warfarin Sodium
MajorMiconazole (including oral gel) inhibits warfarin metabolism, causing marked INR rise and serious bleeding.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Avoid if possible; otherwise monitor INR closely and reduce warfarin dose.