Rofusis Roflumilast Betahistine Mesilate
ModerateThe text names no interaction between roflumilast and betahistine mesilate. It only says that betahistine is a histamine analogue, so taking it at the same time as H1 antagonists may cause the two medicines to weaken each other's effect.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.