Alkixen Crizotinib Phenobarbital
MajorCrizotinib and phenobarbital should not be taken together. Phenobarbital is a strong CYP3A inducer, which means it speeds up the liver enzyme that breaks down many medicines. The leaflet says to avoid using crizotinib at the same time as strong inducers like this one. If you take phenobarbital and have been prescribed crizotinib, tell your doctor before starting. Do not stop or change either medicine on your own.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.