Acaluxen Acalabrutinib Diltiazem Hydrochloride
ModerateComputer simulations (known as PBPK simulations) looked at what happens when Acalabrutinib is taken with diltiazem, a moderate CYP3A inhibitor. They showed that taking the two together raised the peak level (Cmax) of Acalabrutinib in the blood, and its overall exposure (AUC) rose by 2 to almost 3 times.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.