Meth-50 IV Methotrexate Ibuprofen
MajorAvoid taking ibuprofen together with high doses of methotrexate, as with other NSAIDs.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
What to do: Do not take ibuprofen with high-dose methotrexate unless your doctor has said so.