Osimatab 80 Osimertinib Cyclosporine
MajorAvoid using Osimertinib together with other drugs that are sensitive substrates of CYP3A, breast cancer resistance protein (BCRP), or CYP1A2 and have a narrow therapeutic index, such as Fentanyl, Cyclosporine, Quinidine, Ergot Alkaloids, Phenytoin, and Carbamazepine. The list is not complete. Osimertinib can raise or lower the levels of these drugs in the blood, so Cyclosporine's effect may go up or down when the two are taken together.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.