Cystosan Pentosan Polysulfate Sodium Warfarin Sodium
ModerateIn a study of healthy volunteers, some took Pentosan Polysulfate Sodium (Cystosan) 100 mg capsules every 8 hours for 7 days, while others took a dummy capsule (placebo). Everyone's warfarin dose was adjusted until their INR, a blood test that shows how thin the blood is, was between 1.4 and 1.8. Warfarin levels in the body, both the R and S forms, were about the same whether or not Cystosan was taken. INR readings were also similar with Cystosan and with the placebo. So in this study, Cystosan did not change how warfarin behaved in the body or how much it thinned the blood.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.