ALECTA 150 CAPSULE Alectinib St. John's Wort
ModerateThe leaflet text for alectinib doesn't mention St. John's Wort by name, so it gives no specific interaction between the two. It does say that CYP3A4 is the main enzyme that breaks down alectinib and its active product M4, with CYP3A accounting for 40% to 50% of total liver metabolism. It also says that when a strong CYP3A inducer (rifampicin) was given with alectinib, the levels of alectinib in the body fell.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.