Nibalap Lapatinib Ketoconazole
ModerateKetoconazole, a CYP3A4 inhibitor, can raise the amount of Lapatinib in the blood. In healthy people who took 200 mg of Ketoconazole twice daily for 7 days, Lapatinib exposure (AUC) rose to about 3.6 times the control level, and its half-life increased to 1.7 times the control level.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.