Aripiprazole is a dopamine antagonist/partial agonist and may reduce the effect of levodopa, worsening Parkinson's symptoms.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Monitor parkinsonian control and adjust the levodopa dose if needed.