Taking axitinib together with phenytoin can lower the level of axitinib in your blood. Phenytoin is one of several strong CYP3A4/5 inducers, which speed up the way the body breaks axitinib down, so the medicine may not work as well as it should.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.