Axinix 5 Axitinib Ketoconazole
ModerateYour body breaks down Axitinib mainly with an enzyme called CYP3A4/5. It uses a few other enzymes (CYP1A2, CYP2C19 and UGT1A1) to a smaller extent. Ketoconazole strongly blocks CYP3A4/5. When healthy volunteers took the two medicines together, the amount of Axitinib in their blood went up.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.