Axinix 5 Axitinib St. John's Wort
MajorAxitinib is broken down in the body mainly by the enzyme CYP3A4/5, and to a smaller extent by CYP1A2, CYP2C19 and UGT1A1. The leaflet text given here does not say how St. John's Wort affects axitinib or what to do if the two are taken together.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.