Additive uterotonic effect can cause uterine hyperstimulation, rupture and fetal distress.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Avoid concurrent use. Allow an adequate interval, per obstetric protocols, after misoprostol before oxytocin.