Meth 2.5 Methotrexate Ciprofloxacin
MajorReduced methotrexate clearance may raise levels, increasing bone marrow and mucosal toxicity.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Monitor blood counts and methotrexate toxicity; consider an alternative antibiotic.