Slipaid 6 Doxepin Cimetidine
ModerateDoxepin is a tricyclic antidepressant, and cimetidine can inhibit cytochrome P450 2D6, the same enzyme group that handles it. When the two are taken together, lower doses than usual may be needed for either doxepin or cimetidine. The leaflet makes this point about drugs that inhibit cytochrome P450 2D6 in general, naming MAO inhibitors, cimetidine and alcohol as examples.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.