Funcid Fluconazole Venetoclax
MajorFluconazole is one of several medicines that can raise the level of Venetoclax in your blood. Fluconazole is a moderate CYP3A inhibitor, meaning it slows down how the body breaks down Venetoclax (CYP3A is the enzyme involved). During the first stage of treatment and while the dose is still being built up, taking Venetoclax with fluconazole should be avoided. Strong CYP3A inhibitors such as itraconazole, ketoconazole, posaconazole, voriconazole, clarithromycin and ritonavir are a stricter case: they must not be taken with Venetoclax at that stage, because they raise the risk of TLS.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.