Drug Interaction Checker

Find out if your medicines are safe to take together.

1 Add each medicine you take: the brand on the box or the medicine inside it.
2 We check every pair, including each ingredient of combination medicines.
3 See what could happen and what to do, in plain language.

Your medicines

Serious interaction found

At least one pair of your medicines should not be taken together without a doctor's advice. Read the details below and talk to your doctor or pharmacist before your next dose.

1 Major 1 Moderate 1 pair checked

2 interactions

Xibu Dexibuprofen (S Ibuprofen) Methotrexate

Major

NSAIDs reduce methotrexate clearance, risking severe myelosuppression and toxicity.

What should I do?

These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.

Clinical management: Avoid with high-dose methotrexate; with low dose monitor blood counts and renal function.

Xibu contains Dexibuprofen Methotrexate

Moderate

Dexibuprofen can interact with several other medicines when they are taken at the same time. The leaflet names anticoagulants (blood thinners), hydantoin and sulfonamide medicines, ticlopidine, lithium, other NSAIDs, ACE inhibitors, beta blockers, cyclosporine, tacrolimus, corticosteroids, digoxin, pentoxifylline, phenytoin, probenecid, sulfinpyrazone, sulfonylureas, thiazide and thiazide-type diuretics, and zidovudine. Methotrexate is also on this list. So if you take Dexibuprofen and Methotrexate together, an interaction has been noticed. Check with your doctor or pharmacist before combining them.

What should I do?

These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.

Feeling unwell after taking your medicines? For an emergency call 999. For free advice from a doctor, call the 16263 health line (Shasthya Batayon), any time.

What do Major, Moderate and Minor mean?

Major

The combination can cause serious harm or stop a medicine from working. Usually avoided, or only used with close medical supervision.

Moderate

The combination may need care: a different dose, taking them at different times, or extra check-ups.

Minor

Little or no effect is expected. Usually nothing needs to change.

Duplicate

Two of your medicines contain the same ingredient, which can add up to a double dose.

Important: This checker lists interactions found in medicine leaflets and may not be complete. It does not know your dose, your health conditions, or food and supplement interactions. Never start, stop or change a medicine because of this tool alone: ask a registered doctor or pharmacist.