Milam Midazolam Ketoconazole
MajorKetoconazole greatly increases midazolam exposure, causing profound, prolonged sedation and respiratory depression.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Oral midazolam contraindicated; reduce IV dose and monitor closely.