Lanso Lansoprazole Methotrexate
MajorPPIs can delay methotrexate clearance at high doses, raising toxicity.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
What to do: Withhold PPI around high-dose methotrexate; monitor levels.