Malomin Pyrimethamine Roflumilast
ModerateThe text only gives a case report of an interaction between a medicine containing pyrimethamine (taken together with dapsone) and ethanol, and it says nothing about how roflumilast and pyrimethamine act together. So no interaction between roflumilast and pyrimethamine is described here.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.