Rifajap Rifampicin Apremilast
MajorTaking rifampicin along with apremilast lowers how much apremilast gets into the body. Rifampin is a strong enzyme inducer for cytochrome P450, so it speeds up the breakdown of apremilast and that reduces the amount that stays in the system. Because of this, using the two together is not recommended.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.