Diafon Metformin Hydrochloride Morphine Sulphate
ModerateMorphine is one of several drugs (others include digoxin, quinine and trimethoprim) that the kidneys clear by tubular secretion. In theory, when taken with Metformin Hydrochloride, the two can compete for the same kidney transport pathways, which could possibly raise the level of one or both drugs in the body. The leaflet describes this as a theoretical risk rather than something that has been shown to happen.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.