H-Selax Salbutamol Roflumilast
ModerateThere is one case report of salbutamol increasing the effect of betahistine. That report doesn't name roflumilast, so the text gives no information on how roflumilast and salbutamol act together, and it offers no advice about taking them together.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.