G-Aspirin Aspirin Methotrexate
MajorSalicylates reduce methotrexate clearance, risking severe bone marrow suppression and toxicity.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Avoid with high-dose aspirin; with low-dose methotrexate monitor blood counts closely.