Phentin Phenytoin Sodium Imatinib Mesylate
MajorPhenytoin induces CYP3A4 and substantially lowers imatinib levels.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Avoid combination, or increase the imatinib dose with close monitoring.