Zenestrim Clotrimazole Tacrolimus
ModerateOral/absorbed clotrimazole inhibits CYP3A4 and can raise tacrolimus levels, increasing toxicity.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.
Clinical management: Monitor tacrolimus trough levels and renal function when using oral clotrimazole.