Vorifast Voriconazole Tacrolimus
MajorTacrolimus levels rise severalfold, causing nephrotoxicity and neurotoxicity.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Reduce tacrolimus dose by about two thirds and monitor trough levels.